acute kidney injury, chronic kidney disease, diabetic nephropathy, development, matrix biology, hypertension, growth factors, eicosanoid biology, gene delivery, endothelial cell biology, bioartificial kidney
Integrins, transmembrane receptor for extracellular matrix components, are essential regulators of cell-extracellular matrix interactions, and research in the VCKD is investigating their role in progressive kidney disease.
The Hudson lab focuses on the molecular mechanisisms governing collagen IV chain assembly. In addtion, the lab is interesting in defining the key amino acids within the collagen IV chains govering binding to integrins α1β1 and α2β1 and mediating their cellular signaling in healthy and diseased kidneys.
The Gewin lab examines how growth factors such as TGF-beta modulate the response to renal epithelial injury, in part, through altered expression and activation of the collagen binding receptor integrins,
The Pozzi lab studies the molecular bases whereby integrins α1β1 and α2β1, two major collagen binding receptors, regulate collagen homeostasis in healthy and diseased kidneys. We focus our research on the interplay between integrins and growth factors receptors, such as EGF and TGF-β receptors, in the regulation of collagen synthesis in the course of kidney glomerular and tubular injury.
The Zent lab studies basic mechanisms of integrin function using the kidney as a model organ. The main focus of the lab is to define the mechanisms whereby integrins regulate cell function and signaling; define how integrin cytoplasmic tails interact with cytoplasmic proteins to regulate cell function and define the structural determinants of specificity of integrin-dependent signaling. The major techniques used to answer these questions include the making and characterization of transgenic mice, cell biology and biochemical techniques as well as structural methodologies including 3-dimensional nuclear magnetic resonance.